Activation of pleasure receptors will help in the fight against drug addiction

Does running improve your mood? And how! The study showed that the "second wind" effect remains even on the day after training, even without the help of another psychological "reward such as alcohol or sweets.

The activity of opioid receptors in the brain makes people enjoy training
Studies have confirmed that training activates areas of pleasure and reward in the brain in the same way as dangerous drugs do. Because therapy against addiction includes a lot of physical exercises. Scientists from the University of Missouri found that the activation of pleasure receptors and rewards in the brain can simulate the effect of using a drug without actually using it.

A team of scientists led by Professor Frank Booth of the College of Veterinary Medicine bred rats inclined either to extreme activity, or to extreme laziness. They then injected them with substances aimed at activating or deactivating mu-opioid receptors that affect the gene, which releases the dopamine, the neurotransmitter of pleasure. It turned out t

hat activation of receptors in active rats reduced their desire to move.

Before that, active rodents were constantly running around in the wheel. But after activation of mu-opioid receptors, the mobility was sharply limited. Since physical activity and addiction to substances cause the same chemical reactions in the brain, that activation of receptors in people with drug or alcohol dependence will lead to suppression of craving for dangerous substances.

A study of rat brain showed that their receptors for remuneration were 400% more active than the receptors of lazy rats. Thus, these rodents were able to receive many times more pleasure in activating mu-opioid receptors in any way. Because they were ready to run all day.

After disabling mu-opioid receptors in active rats, a similar decrease in activity occurred, but not as dramatically as when activated. However, the effect on the receptors of lazy rodents did not have a significant effect on their behavior.

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